How is polyarteritis nodosa (PAN) treated?

Updated: Dec 17, 2020
  • Author: Dana Jacobs-Kosmin, MD, FACP; Chief Editor: Herbert S Diamond, MD  more...
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Corticosteroids are the cornerstone of treatment. Additional courses include the following:

  • Idiopathic PAN that is steroid refractory or includes major organ involvement: corticosteroids plus cyclophosphamide are the standard of care
  • Hepatitis B–related PAN: corticosteroids with antiviral agents (eg, vidarabine, interferon alpha-2b) and plasmapheresis
  • In patients with steroid-refractory and recurrent PAN, case reports describe response to treatment with biologic agents (eg, infliximab, etanercept, tocilizumab, tofacitinib, rituximab)
  • Severe PAN: plasma exchange has been used

See Treatment and Medication.

For patient education information, see What Is Polyarteritis Nodosa?.

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