Which agents are used to treat osteoporosis?

Updated: Jan 20, 2021
  • Author: Rachel Elizabeth Whitaker Elam, MD, MSc; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Pharmacologic therapy for osteoporosis includes most commonly the use of antiresorptive agents to decrease bone resorption, such as bisphosphonates, denosumab, and the selective estrogen-receptor modulator (SERM) raloxifene. Pharmacologic options also include anabolic agents to promote bone formation in higher-risk patients with osteoporosis; the parathyroid hormone analogues teriparatide and abaloparatide are anabolic agents. Romosozumab is an uncoupling agent that both stimulates the formation of bone and acts as an antiresorptive. All therapies should be given with adequate calcium and vitamin D intakes.


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