What are the AACE recommendations on choosing medications to treat osteoporosis?

Updated: Sep 26, 2019
  • Author: Monique Bethel, MD; Chief Editor: Herbert S Diamond, MD  more...
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Guidelines from the American Association of Clinical Endocrinologists (AACE), published in 2010, include the following recommendations for choosing drugs to treat osteoporosis [11] :

  • First-line agents: alendronate, risedronate, zoledronic acid, denosumab

  • Second-line agent: ibandronate

  • Second- or third-line agent: raloxifene

  • Last-line agent: calcitonin

  • Treatment for patients with very high fracture risk or in whom bisphosphonate therapy has failed: teriparatide

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