What is the role of estrogen-progestin therapy in the treatment of osteoporosis?

Updated: Jan 20, 2021
  • Author: Rachel Elizabeth Whitaker Elam, MD, MSc; Chief Editor: Herbert S Diamond, MD  more...
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Estrogen-progestin therapy is no longer considered a first-line approach for the treatment of osteoporosis in postmenopausal women, because it has been linked to an increased risk for breast cancer, stroke, venous thromboembolism, and perhaps coronary disease. Estrogen is now recommended only if patients are also seeking relief of postmenopausal symptoms.

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