When is teriparatide (Forteo) indicated in the treatment of osteoporosis?

Updated: Sep 26, 2019
  • Author: Monique Bethel, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Use of teriparatide for atypical fractures has not been studied in large randomized controlled trials due to the small numbers of atypical fractures. Gomberg et al reported a case of successful healing of bilateral subtrochanteric stress fractures in a postmenopausal woman who had used a bisphosphonate for 13 years. [161] A small case series showed that teriparatide may have potential in promoting healing of atypical fractures with radiolucent line in an incomplete fracture. [162]

For osteonecrosis of the jaw (ONJ), teriparatide may be a useful adjunctive therapy. Three cases have been reported in which teriparatide has been used successfully in patients with bisphosphonate-associated ONJ. [163, 164, 165]


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