What do high elevations of bone-specific alkaline phosphatase (BSAP) suggest in the workup of osteoporosis?

Updated: Jan 20, 2021
  • Author: Rachel Elizabeth Whitaker Elam, MD, MSc; Chief Editor: Herbert S Diamond, MD  more...
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Answer

BSAP is nonspecific and can be mildly elevated in patients with fractures. In addition, patients with hyperparathyroidism, Paget disease, or osteomalacia can have elevations of BSAP. Serum OC levels, if high, indicate a high-turnover type of osteoporosis. [121] Elevation of urinary NTX-1 (> 40 nmol bone collagen equivalent per mmol urinary creatine) indicates a high-turnover state.


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