Which serum markers of bone resorption are used in the diagnosis of osteoporosis?

Updated: Jan 20, 2021
  • Author: Rachel Elizabeth Whitaker Elam, MD, MSc; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Currently available serum markers of bone resorption include the following:

  • Cross-linked C-telopeptide of type 1 collagen (ICTP)
  • Tartrate-resistant acid phosphatase 5b (TRAP-5b)
  • N-telopeptide of type 1 collagen cross-links (NTX-1) (also available as a urinary marker)
  • C-telopeptide of type 1 collagen cross-links (CTX-1) (also available as a urinary marker)

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