What is the sensitivity of the WHO fracture-risk algorithm (FRAX) for perimenopausal and early-menopausal women?

Updated: Sep 26, 2019
  • Author: Monique Bethel, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The FRAX tool has a low sensitivity for predicting fracture risk in perimenopausal and early-menopausal women. In a study by Trémollieres et al, FRAX had 50% sensitivity in the 30% of women in the study who were at the highest risk. [87] FRAX also does not include risk of falls; 90% of hip fractures [88] and the majority of Colles fractures are associated with falls. [89]  

The Garvan fracture risk tool is not as widely used as the FRAX but is another validated fracture prediction tool that does account for falls, and may be a better tool for use in men. [90]


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