What are lesser known factors in the pathogenesis of osteoporosis?

Updated: Jan 20, 2021
  • Author: Rachel Elizabeth Whitaker Elam, MD, MSc; Chief Editor: Herbert S Diamond, MD  more...
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Other factors implicated in the pathogenesis of osteoporosis include the following [13] :

  • Polymorphisms in the vitamin D receptor
  • Alterations in insulin-like growth factor-1, bone morphogenic protein, prostaglandin E 2, nitrous oxide, and leukotrienes
  • Collagen abnormalities
  • Leptin-related adrenergic signaling

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