Why does rapid bone remodeling result in an increased risk of osteoporosis and fracture?

Updated: Jan 20, 2021
  • Author: Rachel Elizabeth Whitaker Elam, MD, MSc; Chief Editor: Herbert S Diamond, MD  more...
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Furthermore, in periods of rapid remodeling (eg, after menopause), bone is at an increased risk for fracture because the newly produced bone is less densely mineralized, the resorption sites are temporarily unfilled, and the isomerization and maturation of collagen are impaired. [21]

Activation frequency reflecting the bone remodelling rate increased to double at menopause, triple by 13 years later, and remained at high levels in osteoporotic patients, which contributes to increases in age-related skeletal fragility in women. Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients.

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