Which lab studies are included in the workup of osteoporosis?

Updated: Sep 26, 2019
  • Author: Monique Bethel, MD; Chief Editor: Herbert S Diamond, MD  more...
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Baseline laboratory studies include the following:

  • Complete blood count: May reveal anemia

  • Serum chemistry levels: Usually normal in persons with primary osteoporosis

  • Liver function tests

  • Thyroid-stimulating hormone level: Thyroid dysfunction has been associated with osteoporosis

  • 25-Hydroxyvitamin D level: Vitamin D insufficiency can predispose to osteoporosis

  • Serum protein electrophoresis: Multiple myeloma may be associated with osteoporosis

  • 24 hour urine calcium/creatinine: Hypercalciuria may be associated with osteoporosis; further investigation with measurement of intact parathyroid hormone and urine pH may be indicated; hypocalciuria may indicate malabsorption, which should be further evaluated with a serum vitamin D measurement and consideration of testing for malabsorption syndromes such as celiac sprue

  • Testosterone (total and/or free) and luteinizing hormone/follicle-stimulating hormone: Male hypogonadism is associated with osteoporosis

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