Which medications in the drug class Corticosteroids are used in the treatment of Osteoarthritis?

Updated: Jun 10, 2020
  • Author: Carlos J Lozada, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Corticosteroids

Intra-articular pharmacologic therapy includes corticosteroid injection and viscosupplementation. Steroid injections generally result in a clinically and statistically significant reduction in osteoarthritic knee pain as soon as 1 week after injection. The effect may last, on average, anywhere from 4 to 6 weeks per injection, but the benefit is unlikely to continue beyond that time frame. However, triamcinolone acetonide extended-release injectable suspension (Zilretta) may reduce pain intensity for up to 12 weeks.

Triamcinolone acetonide extended-release injectable suspension (Zilretta)

Corticosteroid with anti-inflammatory and immunomodulating properties. It binds to and activates the glucocorticoid receptor, leading to activation of anti-inflammatory transcription factors (eg, lipocortins). It also inhibits inflammatory transduction pathways by blocking arachidonic acid release and preventing prostaglandin and leukotriene synthesis. Indicated for management of osteoarthritis knee pain. Administered as a single intra-articular injection. Not intended for repeat administration.

Triamcinolone acetonide injectable suspension (Kenalog-40)

Corticosteroid with anti-inflammatory and immunomodulating properties; it binds to and activates the glucocorticoid receptor, leading to activation of anti-inflammatory transcription factors (eg, lipocortins); it also inhibits inflammatory transduction pathways by blocking arachidonic acid release and preventing prostaglandin and leukotriene synthesis. Indicated for intra-articular injection for pain management of osteoarthritis.

Methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol, A-Methapred)

Methylprednisolone decreases inflammation by suppressing migration of polymorphonuclear leukocytes (PMNs) and reversing increased capillary permeability.

Betamethasone (Celestone Soluspan)

Betamethasone decreases inflammation by suppressing migration of PMNs and reversing increased capillary permeability. It affects the production of lymphokines and has an inhibitory effect on Langerhans cells.


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