What are the risk factors for osteoarthritis (OA)?

Updated: Oct 12, 2020
  • Author: Carlos J Lozada, MD; Chief Editor: Herbert S Diamond, MD  more...
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Risk factors for osteoarthritis include the following [34, 35, 36, 37] :

  • Age

  • Obesity [38, 39, 40]

  • Trauma

  • Genetics (significant family history)

  • Reduced levels of sex hormones

  • Muscle weakness [41]

  • Repetitive use (ie, jobs requiring heavy labor and bending) [42]

  • Infection

  • Crystal deposition

  • Acromegaly

  • Previous inflammatory arthritis (eg, burnt-out rheumatoid arthritis)

  • Heritable metabolic causes (eg, alkaptonuria, hemochromatosis, Wilson disease)

  • Hemoglobinopathies (eg, sickle cell disease and thalassemia)

  • Neuropathic disorders leading to a Charcot joint (eg, syringomyelia, tabes dorsalis, and diabetes)

  • Underlying morphologic risk factors (eg, congenital hip dislocation and slipped femoral capital epiphysis)

  • Disorders of bone (eg, Paget disease and avascular necrosis)

  • Previous surgical procedures (eg, meniscectomy)

  • Diabetes mellitus [43]

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