Which inflammatory molecules are associated with osteoarthritis (OA)?

Updated: Jun 10, 2020
  • Author: Carlos J Lozada, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Studies of interleukin-17 (IL-17), a proinflammatory cytokine, have found increased IL-17 levels in the synovium of osteoarthritis joints, as is seen in inflammatory arthritis (ie, rheumatoid arthritis). [26] Other inflammatory molecules that have been associated with osteoarthritis include 15‐hydroxyeicosatetraenoic acid, prostaglandin E2, IL‐1β, IL‐1 receptor antagonist, and uric acid. [27]


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