Which medications in the drug class Calcium Channel Blocker/COX-2 Inhibitor Combination are used in the treatment of Osteoarthritis?

Updated: Jun 10, 2020
  • Author: Carlos J Lozada, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Calcium Channel Blocker/COX-2 Inhibitor Combination

This combination provides blood pressure lowering affect from amlodipine to reduce the risk of fatal and nonfatal CV events, primarily strokes and myocardial infarctions.

Celecoxib/amlodipine (Consensi)

Celecoxib inhibits cyclooxygenase (COX)-2 which decreases formation of prostaglandin synthesis. Elicits analgesic, anti-inflammatory, and antipyretic properties. Amlodipine, a calcium channel blocker, Inhibits transmembrane influx of extracellular calcium ions across membranes of myocardial cells and vascular smooth muscle cells without changing serum calcium concentrations; this inhibits cardiac and vascular smooth muscle contraction, thereby dilating main coronary and systemic arteries. In clinical trials, the combination lowered diastolic and systolic blood pressure (both daytime and nighttime measurements) similarly to an equal dose of amlodipine. It is indicated in adults for whom treatment with both amlodipine for hypertension and celecoxib for osteoarthritis are appropriate.


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