How is lupus nephritis staged?

Updated: Mar 04, 2019
  • Author: Lawrence H Brent, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Evaluating renal function in patients with systemic lupus erythematosus (SLE) to detect any renal involvement early is important because early detection and treatment can significantly improve renal outcome. [26]

Renal biopsy should be considered in any patient with SLE who has clinical or laboratory evidence of active nephritis, especially upon the first episode of nephritis. [26, 32]

Lupus nephritis is staged according to the classification revised by the International Society of Nephrology (ISN) and the Renal Pathology Society (RPS) in 2003. This classification is based on light microscopy, immunofluorescence, and electron microscopy findings from renal biopsy specimens.

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