What genes play a role in the etiology of lupus nephritis?

Updated: Sep 22, 2020
  • Author: Lawrence H Brent, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Other relevant genes include the following:

  • Cytokine genes - Certain polymorphisms of the IL10 gene (high producers) and possibly the IL1RN and TNFA genes (low producers) are associated with SLE

  • Mannose-binding lectin genes - These gene polymorphisms are associated with an increased risk of SLE

  • Apoptosis genes - Defects of several apoptosis genes are associated with lupuslike syndromes in mice and, rarely, SLE in humans, including CD95 (Fas) and CD178 (FasL)

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