Which complement genes have an etiologic role in lupus nephritis?

Updated: Mar 04, 2019
  • Author: Lawrence H Brent, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Complement genes include the following:

  • C1Q, C1R, and C1S deficiencies are associated with SLE, lupus nephritis, and production of anti-dsDNA

  • C2 and C4 deficiencies are associated with SLE or lupuslike syndrome

  • C4A and C4B (possibly) gene deletions are associated with SLE


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