What is the role of human leukocyte antigen (HLA) class II genes in the etiology of lupus nephritis?

Updated: Mar 04, 2019
  • Author: Lawrence H Brent, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Human leukocyte antigen (HLA) class II genes include the following:

  • HLA-DR2 and HLA-DR3 are associated with SLE

  • HLA-DR4 is associated with a lower prevalence of SLE and appears to be protective


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