How are specific comorbidities managed in familial Mediterranean fever (FMF)?

Updated: Apr 07, 2020
  • Author: John O Meyerhoff, MD; Chief Editor: Herbert S Diamond, MD  more...
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Other therapeutic measures

Additional treatment options include the following:

  • Hemodialysis can be used for patients who develop renal failure. Peritoneal dialysis tends to increase the number of abdominal attacks.
  • Patients who experience episodes of prolonged myalgia with fever and severe pain may need treatment with prednisone (1 mg/kg) for as long as 6 weeks.
  • Patients with exertional lower extremity muscle pain respond to rest.
  • Treat patients with fibromyalgia with the usual agents for this condition.
  • Treat patients who develop seronegative spondyloarthropathy with nonsteroidal anti-inflammatory drugs as first-line therapy. Some of these patients may require treatment with TNF-alpha blockers and should receive follow-up care by a rheumatologist. [34]

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