What is the role of lab studies in the workup of familial Mediterranean fever (FMF)?

Updated: Apr 07, 2020
  • Author: John O Meyerhoff, MD; Chief Editor: Herbert S Diamond, MD  more...
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Results of routine blood tests performed during the acute attacks of familial Mediterranean fever (FMF) are nonspecific. Levels of acute-phase reactants (ie, C-reactive protein, erythrocyte sedimentation rate, amyloid A protein, fibrinogen) are elevated. The white blood cell count is usually elevated during an attack. The elevated levels rapidly return to the reference range as the attack abates.

On urine studies, proteinuria should raise a concern about possible amyloidosis. For unknown reasons, hematuria occurs in 5% of patients.

In patients with arthritis during attack, synovial fluid is inflammatory, with cell counts as high as 100,000/µL.

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