What are the signs and symptoms of familial Mediterranean fever (FMF)?

Updated: May 14, 2018
  • Author: John O Meyerhoff, MD; Chief Editor: Herbert S Diamond, MD  more...
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The following may also be features of FMF:

  • Dermatologic manifestations - As many as 50% of patients with FMF report erysipelaslike rashes on the lower extremities, particularly below the knees; rash and fever may be the only manifestations of attacks

  • Muscle symptoms - Severe myalgia may last 3-6 weeks; symptoms are consistent with fibromyalgia; these episodes do not respond to colchicine therapy

  • Pelvic symptoms - Female patients with FMF may have episodes of pelvic inflammatory disease

  • Scrotal attacks - In males, inflammation of the tunica vaginalis testis may mimic episodes of testicular torsion

  • Vasculitis - An increased frequency of Henoch-Schönlein purpura and polyarteritis nodosa is reported in persons with FMF, even in children; Behçet disease is also more common

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