What is familial Mediterranean fever (FMF)?

Updated: Apr 07, 2020
  • Author: John O Meyerhoff, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Familial Mediterranean fever (FMF), also known as recurrent polyserositis, is an autosomal recessive autoinflammatory disorder characterized mainly by brief recurrent episodes of peritonitis, pleuritis, and arthritis, usually with accompanying fever. See Presentation. As the name indicates, FMF occurs within families and is most common in individuals of Mediterranean descent. [1]

Genetic testing is now available for FMF. Testing for a limited number of genes may be appropriate in patients with a known ethnic background. See Workup.

Colchicine is extremely effective in preventing attacks of FMF and preventing the development of amyloidosis. Biologic agents (eg, anakinra, rilonacept, canakinumab) are used for second-line therapy. See Treatment and Medication.


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