What comorbidities do the ACR guidelines recommend as considerations in the clinical evaluation of gout?

Updated: Jan 26, 2021
  • Author: Bruce M Rothschild, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The ACR recommends the following checklist of comorbidities as appropriate to consider in the clinical evaluation of patients with gout, and to evaluate if clinically indicated (all level C) [125] :

  • Obesity, dietary factors
  • Excessive alcohol intake
  • Metabolic syndrome, type 2 diabetes mellitus
  • Hypertension
  • Hyperlipidemia, modifiable risk factors for coronary artery disease or stroke
  • Serum urate–elevating medications
  • History of urolithiasis
  • Chronic kidney, glomerular, or interstitial renal disease (eg, analgesic nephropathy, polycystic kidney disease)
  • In selected cases, potential genetic or acquired causes of uric acid overproduction (eg, inborn error of purine metabolism or psoriasis, myeloproliferative or lymphoproliferative disease)
  • Lead intoxication

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