What is the efficacy of lesinurad in the treatment of gout?

Updated: Jan 26, 2021
  • Author: Bruce M Rothschild, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Approval was based on 3 randomized, placebo-controlled studies in combination with a xanthine oxidase inhibitor involving 1,537 participants for up to 12 months. Participants treated with lesinurad plus allopurinol or febuxostat experienced reduced serum uric acid levels compared with placebo. [176]

In a randomized double-blind study of 227 patients with an inadequate response to allopurinol, the addition of lesinurad to the prestudy allopurinol dose resulted in significant mean reductions of serum uric acid levels from baseline. Levels decreased 16%, 22%, and 30% with lesurinad doses of 200, 400, and 600 mg, respectively. In comparison, patients receiving placebo demonstrated a mean 3% increase in serum uric acid levels (P < 0.0001, all doses vs placebo). Similar results were observed in patients with mild or moderate renal insufficiency. [177]


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