What are the treat-to-target recommendations for gout?

Updated: Jan 26, 2021
  • Author: Bruce M Rothschild, MD; Chief Editor: Herbert S Diamond, MD  more...
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An international working group has developed treat-to-target recommendations for gout. In the absence of randomized trials comparing standard treatment with treat-to-target approaches in gout, the recommendations were based on indirect evidence and expert recommendations. [134, 135] The treatment targets are as follows:

  • Serum uric acid levels reduced below 6 mg/dL (5 mg/dL in patients with severe gout, such as tophi or frequent attacks) and maintained there
  • Tophi reduced in number or size
  • Pain reduction
  • Absence of attacks

Patients should have regular monitoring (eg, every 3-6 months) to assess whether targets are being met.

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