Which diseases are associated with hyperuricemia and gout?

Updated: Jan 26, 2021
  • Author: Bruce M Rothschild, MD; Chief Editor: Herbert S Diamond, MD  more...
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Hyperuricemia and gout are associated with an increased overall likelihood of mortality. Whether this is directly attributable to hyperuricemia or gout or to gout-associated diseases (eg, insulin resistance, type 2 diabetes mellitus, abdominal obesity, hypercholesterolemia, or hypertension) has been much debated. [66, 67, 68]

Although no evidence has shown that gout or hyperuricemia causes any of these disorders, elevated urate levels have been shown to correlate with elevated blood pressure in adolescents. [69] Among middle-aged men, hyperuricemia is a significant independent risk factor for death from cardiovascular disease. [70] A meta-analysis found an independent association between gout and cardiovascular mortality as well as all-cause mortality. [68]

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