What is the difference between primary and secondary gout?

Updated: Jan 26, 2021
  • Author: Bruce M Rothschild, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Gout may be either primary or secondary (see Etiology). Primary gout is related to underexcretion or overproduction of uric acid, often associated with a mix of dietary excesses or alcohol overuse and metabolic syndrome. Secondary gout is related to medications or conditions that cause hyperuricemia, such as the following [5] :

  • Myeloproliferative diseases or their treatment
  • Therapeutic regimens that produce hyperuricemia
  • Renal failure
  • Renal tubular disorders
  • Lead poisoning
  • Hyperproliferative skin disorders
  • Enzymatic defects (eg, deficient hypoxanthine-guanine phosphoribosyl transferase, glycogen storage diseases)

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