Which agents are used to lower uric acid levels in gout?

Updated: Jan 26, 2021
  • Author: Bruce M Rothschild, MD; Chief Editor: Herbert S Diamond, MD  more...
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Long-term management of gout is focused on lowering uric acid levels. Agents used include the following:

  • Allopurinol

  • Febuxostat

  • Probenecid

Because these agents change serum and tissue uric acid levels, they may precipitate acute attacks of gout. This undesired effect may be reduced by prophylaxis with the following:

  • Colchicine or low-dose NSAIDs

  • Low-dose prednisone (if patients cannot take colchicine or NSAIDs)

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