What agents are used in the treatment of acute crystal-induced arthritis in gout?

Updated: Jan 26, 2021
  • Author: Bruce M Rothschild, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Acute treatment of proven crystal-induced arthritis is directed at relief of the pain and inflammation. Agents used in this setting include the following:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin

  • Corticosteroids

  • Colchicine (now less commonly used for acute gout than it once was)

  • Adrenocorticotropic hormone (ACTH)

  • Combinations of drugs (colchicine plus NSAIDs, oral corticosteroids plus colchicine, intra-articular steroids plus colchicine or NSAIDs)

Therapy to control the underlying hyperuricemia generally is contraindicated until the acute attack is controlled (unless kidneys are at risk because of an unusually heavy uric acid load).


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