What is the role of genetics in the development of fibromyalgia?

Updated: Nov 14, 2018
  • Author: Chad S Boomershine, MD, PhD, CPI, CPT; Chief Editor: Herbert S Diamond, MD  more...
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Answer

The extremely important genetic contribution to fibromyalgia and related central sensitivity syndromes was first suggested by family studies. [48, 49] Subsequently, the application of sophisticated genotyping and statistical methodology has provided a detailed view of this relationship. [50, 51]

For example, altered serotonin metabolism in a subgroup of patients with fibromyalgia has been linked to a genotype of the promoter region of the serotonin transporter gene. [52] Single-nucleotide polymorphisms in the genes for catecholamine-O-methyltransferase (which inactivates catecholamines) and β2-adrenergic receptors have been linked to increased pain perception. [32, 36, 53]


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