What is the role of genetics in the development of fibromyalgia?

Updated: Apr 23, 2020
  • Author: Chad S Boomershine, MD, PhD, CPI, CPT; Chief Editor: Herbert S Diamond, MD  more...
  • Print

The extremely important genetic contribution to fibromyalgia and related central sensitivity syndromes was first suggested by family studies. [48, 49] Subsequently, the application of sophisticated genotyping and statistical methodology has provided a detailed view of this relationship. [50, 51]

For example, altered serotonin metabolism in a subgroup of patients with fibromyalgia has been linked to a genotype of the promoter region of the serotonin transporter gene. [52] Single-nucleotide polymorphisms in the genes for catecholamine-O-methyltransferase (which inactivates catecholamines) and β2-adrenergic receptors have been linked to increased pain perception. [32, 36, 53]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!