Which medications are used in the treatment of fibromyalgia?

Updated: Apr 23, 2020
  • Author: Chad S Boomershine, MD, PhD, CPI, CPT; Chief Editor: Herbert S Diamond, MD  more...
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Always combine pharmacologic and nonpharmacologic therapy in the treatment of fibromyalgia. Aggressively treat comorbid depression.

Medications used in the management of fibromyalgia include the following:

  • Analgesics (eg, tramadol)

  • Antianxiety/hypnotic agents (eg, alprazolam, clonazepam, zolpidem, zaleplon, trazodone, buspirone, temazepam, sodium oxybate)

  • Skeletal muscle relaxants (eg, cyclobenzaprine)

  • Antidepressants (eg, amitriptyline, duloxetine, milnacipran, venlafaxine, desvenlafaxine)

  • Anticonvulsants (eg, pregabalin, gabapentin, tiagabine)

  • Alpha 2 agonists (eg, clonidine)

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