Which lab tests are used in the workup of fibromyalgia?

Updated: Apr 23, 2020
  • Author: Chad S Boomershine, MD, PhD, CPI, CPT; Chief Editor: Herbert S Diamond, MD  more...
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Although patients with fibromyalgia do not have characteristic or consistent abnormalities on laboratory testing, routine laboratory and imaging studies can help to rule out diseases with similar manifestations and to assist in diagnosis of certain inflammatory diseases that frequently coexist with fibromyalgia. Such tests include the following:

  • Complete blood count with differential

  • Metabolic panel

  • Urinalysis

  • Thyroid-stimulating hormone level

  • 25-hydroxy vitamin D level

  • Vitamin B12 level

  • Iron studies, including iron level, total iron binding capacity, percent saturation, and serum ferritin level

  • Magnesium level

  • Erythrocyte sedimentation rate

  • Antipolymer antibody assay: May provide conclusive evidence for a subgroup of people with fibromyalgia; about 50% of fibromyalgia patients have antipolymer antibodies

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