What is the role of smoking in the etiology of Dupuytren contracture?

Updated: Mar 02, 2020
  • Author: Eva Kovacs, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

A 3-fold increased risk for Dupuytren contracture is seen in individuals who smoke, even when studies control for alcohol use, perhaps due to microvascular impairment. [36] Autoantibodies to connective tissue Significant associations have been found with HLA-DRB1*15, HLA-DR3 and autoantibodies to collagen types I-IV have been reported. [51]


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