What is the role of lab tests in the workup of Behçet disease?

Updated: Dec 21, 2020
  • Author: Nicole Davey-Ranasinghe, MD; Chief Editor: Herbert S Diamond, MD  more...
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Laboratory findings are nonspecific and reflect the inflammatory state.

C-reactive protein levels, erythrocyte sedimentation rate (ESR), leukocyte count, complement components, and acute-phase reactants may all be elevated during an acute attack. Levels of IgA, IgG, alpha-2 globulin, IgM, and immune complexes are occasionally elevated.

In a study of 48 patients with Behçet disease and 47 healthy controls, serum levels of calprotectin were significantly elevated in the Behçet disease group. However, serum calprotectin levels did not correlate with scores on the Behçet Disease Current Activity Form or with measures of depression and anxiety or quality of life. [44]

None of these findings is specific for the diagnosis of Behçet disease, but such findings can corroborate active disease.

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