Which ocular exam findings are characteristic of Behçet disease?

Updated: Dec 21, 2020
  • Author: Nicole Davey-Ranasinghe, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Eye findings may include the following:

  • Anterior uveitis with and without hypopyon formation
  • Posterior uveitis that may cause blindness
  • Glaucoma
  • Synechiae
  • Retinal vasculitis
  • Infarctions
  • Hemorrhage
  • Edematous appearance of the disc, with retinal detachment
  • Leaky retinal vessels revealed by fluorescein angiography, leading to atrophy and fibrosis in some cases

In a retrospective observational case series of 132 patients with Behçet-associated uveitis, the most common presentation was panuveitis, which occurred in 118 patients (89.4%). Bilateral episodes were observed in 100 patients (75.8%). At baseline, best-corrected visual acuity (BCVA) was 20/125 in both eyes. [40]

Other ocular manifestations at presentation included retinal vasculitis (61 eyes, 26.3%), occlusive vasculitis in (59 eyes, 25.4%), and macular edema (42 eyes, 18.1%). Anterior segment complications included glaucoma in 44 eyes (19%) and cataracts in 34 eyes (14.7%). Optic nerve atrophy was the most commonly observed posterior segment complication. BCVA was better than 20/50 at last follow-up in 131 eyes (56.5%). [40]


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