What are neurologic signs and symptoms of Behçet disease?

Updated: Dec 21, 2020
  • Author: Nicole Davey-Ranasinghe, MD; Chief Editor: Herbert S Diamond, MD  more...
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Collectively, neurologic signs and symptoms tend to be an unusual late manifestation, 1-8 years after disease onset. They include the following:

  • Memory tends to be affected in most cases, particularly affecting recall and learning. Orientation, arithmetic, and language are often unaffected.
  • Symptoms are usually parenchymal in nature, predominantly with brainstem involvement. [31]
  • Behavioral changes, primarily apathy or disinhibition, occur in 54% of patients.
  • Seizures and bulbar signs with ophthalmoplegia are less common.

Other less common findings include the following:

  • Infarctions due to vasculitis or thrombosis
  • Meningoencephalitis
  • Lymphocytic meningeal infiltration
  • Demyelinization

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