What is the mortality and morbidity associated with Behçet disease?

Updated: Dec 21, 2020
  • Author: Nicole Davey-Ranasinghe, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Mortality and morbidity data include the following:

  • The mortality rate in a cohort of 817 patients in France was 5% at a median follow-up of 7.7 years [30]
  • Coronary/pulmonary arterial aneurysm rupture in association with Behçet disease carries a high mortality rate
  • Neurologic involvement has been associated with mortality rates up to 20% at 7-year follow-up in one Turkish study [31]
  • Thrombosis may lead to death
  • Central nervous system involvement can lead to permanent deficits or death
  • Eye involvement can result in blindness

In a study comparing 298 pregnancies in 94 Behçet disease patients with 219 pregnancies in 95 healthy controls, women with Behçet disease delivered smaller babies (3214 versus 3351 g, respectively; P= 0.028) and had higher miscarriage rates. The authors suggest vasculitis of the placenta as a possible cause. [32]


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