What is the role of NSAIDS and diuretics in the treatment of carpal tunnel syndrome (CTS)?

Updated: Mar 30, 2020
  • Author: Nigel L Ashworth, MBChB, MSc, FRCPC; Chief Editor: Milton J Klein, DO, MBA  more...
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Nonsteroidal anti-inflammatory drugs (NSAIDs) and/or diuretics may be of benefit against CTS in certain populations (eg patients with fluid retention or with wrist flexor tendinitis). The efficacy of gabapentin, diuretics, and NSAIDs is controversial, however, with guidelines from the American Academy of Orthopaedic Surgeons stating that oral agents are no better than placebo in the treatment of CTS. [41] Additionally, vitamin B-6 and B-12 supplements are of no proven benefit against the disorder. [12]

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