What are the mechanisms of action for epidural steroid injections (ESIs) for back pain?

Updated: Aug 06, 2018
  • Author: Boqing Chen, MD, PhD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Since lumbar radicular pain may originate from inflammation of the epidural space and the nerve root, analgesic effects of corticosteroids most likely are related to the following mechanisms:

  • Inhibition of PLA2 and inflammation

  • Inhibition of neural transmission in nociceptive C fibers

  • Reduction of capillary permeability

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