Which medications in the drug class BPH, Alpha Blockers are used in the treatment of Bladder Dysfunction?

Updated: Jan 04, 2019
  • Author: Gregory T Carter, MD, MS; Chief Editor: Elizabeth A Moberg-Wolff, MD  more...
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BPH, Alpha Blockers

Alpha-adrenergic blockers are used to decrease bladder overactivity.

Prazosin (Minipress)

Prazosin improves urine flow rates by relaxing smooth muscle. This relaxation is produced by blocking alpha1 adrenoceptors in the bladder neck and prostate. When increasing dosages, give the first dose of each increment at bedtime to reduce syncopal episodes. Although dosages higher than 20 mg/day usually do not increase efficacy, some patients may benefit from dosages as high as 40 mg/day.

Phenoxybenzamine (Dibenzyline)

Phenoxybenzamine decreases bladder contractions through long-lasting noncompetitive alpha-adrenergic blockade of the postganglionic synapses at the smooth muscle and exocrine glands.

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