Which medications in the drug class Tricyclic Antidepressants are used in the treatment of Bladder Dysfunction?

Updated: Jan 04, 2019
  • Author: Gregory T Carter, MD, MS; Chief Editor: Elizabeth A Moberg-Wolff, MD  more...
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Tricyclic Antidepressants

TCAs have central and peripheral anticholinergic effects, as well as sedative effects, and block the active reuptake of norepinephrine and serotonin. The exact mechanisms by which these drugs act in the treatment of incontinence, however, are not fully understood. The Agency for Health Care Policy and Research (AHCPR) guidelines caution that TCAs should be reserved for use in carefully evaluated patients.

Imipramine hydrochloride (Tofranil, Tofranil-PM)

Imipramine facilitates urine storage by decreasing bladder contractility and increasing outlet resistance. It inhibits reuptake of norepinephrine or serotonin at the presynaptic neuron.

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