Which medications in the drug class Antidepressants, TCAs are used in the treatment of Brachial Neuritis?

Updated: Oct 13, 2020
  • Author: Nigel L Ashworth, MBChB, MSc, FRCPC; Chief Editor: Milton J Klein, DO, MBA  more...
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Antidepressants, TCAs

Tricyclic antidepressants (TCAs) are a complex group of drugs that have central and peripheral anticholinergic effects and sedative effects. They block the active reuptake of norepinephrine and serotonin.

Nortriptyline (Pamelor)

Low-dose tricyclic antidepressant (TCA) medication for neuropathic pain management. Nortriptyline has demonstrated effectiveness in the treatment of chronic pain. It increases the synaptic concentration of serotonin and norepinephrine in the central nervous system (CNS) by inhibiting their reuptake by the presynaptic neuronal membrane. Additional pharmacodynamic effects, such as desensitization of adenyl cyclase and down-regulation of beta-adrenergic receptors and serotonin receptors, appear to play roles. (Off-label use for this diagnosis)

Doxepin (Silenor)

Low-dose tricyclic antidepressant (TCA) medication for neuropathic pain management. Doxepin increases the concentration of serotonin and norepinephrine in the CNS by inhibiting their reuptake by presynaptic neuronal membrane. It inhibits histamine and acetylcholine activity and has proven useful in treatment of various forms of depression associated with chronic pain. (Off-label use for this diagnosis)

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