Which medications in the drug class GABA Analogs are used in the treatment of Brachial Neuritis?

Updated: Oct 13, 2020
  • Author: Nigel L Ashworth, MBChB, MSc, FRCPC; Chief Editor: Milton J Klein, DO, MBA  more...
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GABA Analogs

GABA analogs are used to alleviate painful dysesthesias, which frequently accompany peripheral neuropathies. Although they have many different mechanisms of action, their use for alleviating neuropathic pain probably depends on their general tendency to reduce neuronal excitability.

Gabapentin (Neurontin, Gralise, Neuraptine, Fanatrex FusePaq)

Gabapentin has properties common to other anticonvulsants and exerts antineuralgic effects. Its exact mechanism of action is not known. Gabapentin is structurally related to gamma-aminobutyric acid (GABA) but does not interact with GABA receptors. It has efficacy at the alpha2-delta subunit. (Off-label use for this condition)

Pregabalin (Lyrica, Lyrica CR)

Pregabalin is a structural derivative of GABA. Its mechanism of action is unknown; it is known to bind with high affinity to alpha2-delta subunits of calcium channels. In vitro, pregabalin reduces calcium-dependent release of several neurotransmitters, possibly by modulating calcium-channel function. (Off-label use for this condition)

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