What is the pathophysiology of brachial neuritis (BN)?

Updated: May 06, 2020
  • Author: Nigel L Ashworth, MBChB, MSc, FRCPC; Chief Editor: Milton J Klein, DO, MBA  more...
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Answer

Brachial neuritis (BN) exists in an inherited and an idiopathic form. In the idiopathic version, the pathophysiology is unknown, but the condition is generally thought to be an immune system–mediated inflammatory reaction against nerve fibers of the brachial plexus. [9, 10, 11, 12, 13] Axonopathy with subsequent Wallerian degeneration appears to predominate, but proximal conduction block has also been described in over 33% of cases in the series by Lo and Mills. [14] The inherited form is autosomal dominant and has been linked to mutations in the SEPT9 gene on chromosome 17q. [15, 16, 17] Septins are involved in the formation of the cytoskeleton and in cell division, but how these mutations result in BN is unknown.


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