What are the less common causes of Guillain-Barre syndrome (GBS)?

Updated: May 04, 2018
  • Author: Michael T Andary, MD, MS; Chief Editor: Milton J Klein, DO, MBA  more...
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Answer

Various events, such as surgery, trauma, and pregnancy, have been reported as possible triggers of GBS, but these associations remain mostly anecdotal.

Case reports cite associations between bariatric and other gastric surgeries, renal transplantation, and epidural anesthesia. [64]

Anecdotal associations include systemic lupus erythematosus, sarcoidosis, lymphoma, and snakebite.

Tumor necrosis factor–alpha polymorphisms with increased expression are associated with many autoimmune and inflammatory diseases, and may increase susceptibility to axonal GBS subtypes. However, the role of these polymorphisms in GBS remains unclear and warrants further investigation. [65]


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