Do vaccines increase or decrease the risk of developing Guillain-Barre syndrome (GBS)?

Updated: Jun 24, 2020
  • Author: Michael T Andary, MD, MS; Chief Editor: Milton J Klein, DO, MBA  more...
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Results from studies into the association between GBS and other vaccines include the following:

  • Data from a large-scale epidemiologic study reported a decreased GBS incidence following administration of tetanus toxoid containing vaccinations when compared with the baseline population [62]

  • An epidemiologic study failed to show any conclusive epidemiologic association between GBS and the hepatitis B vaccine [63]

  • A large Latin American study of more than 2000 children with GBS following a mass measles vaccination program in 1992-1993 failed to establish a statistically significant causal relationship between administration of the measles vaccine and GBS [64]

  • A report from the CDC suggests that recipients of the Menactra meningococcal conjugate vaccine may be at increased risk of GBS [65]

  • Case reports exist regarding group A streptococcal vaccines and the rabies vaccine; however, conclusive, statistically significant evidence is lacking

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