Which treatments are under investigation for corticosteroid-induced myopathy?

Updated: Sep 10, 2019
  • Author: Patrick M Foye, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Preliminary studies on rats suggest that creatine plays a part in the prophylaxis of steroid-induced myopathy. Further studies are needed to explore this possible treatment/prevention option. [26]

Other experimental treatments include IGF-I, branched-chain amino acids, glutamine, and androgens such as testosterone and DHEA. Further studies are needed to correlate the benefits of such treatment. [27] One study demonstrated that the concomitant injection of branched-chain amino acids with dexamethasone seemed to reverse the reduction of total protein concentration induced by the steroid in rat muscles. [28]

Banerjee et al described the successful use of the glucocorticoid-receptor antagonist mifepristone in a pediatric patient with Cushing syndrome, with effects including a significant improvement in myopathy. [29]

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