Which histologic findings indicate corticosteroid-induced myopathy?

Updated: Sep 10, 2019
  • Author: Patrick M Foye, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Answer

Muscle biopsy typically shows a preferential atrophy of type II fibers, particularly the fast-twitch glycolytic fibers (type IIB), with some atrophy of other fiber types. [11, 15] There is a distinct lack of necrosis or regeneration of muscle. Some studies, however, have reported focal and diffuse necrosis of all fiber types, without predilection for type II fibers.


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