What is the role of muscle biopsy in the diagnosis of chronic (classic) corticosteroid-induced myopathy?

Updated: Sep 10, 2019
  • Author: Patrick M Foye, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
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Answer

Muscle biopsy shows preferential atrophy of type II fibers, particularly the fast-twitch glycolytic fibers (type IIB). [11, 15] Some atrophy of other type II fibers and, to a small degree, type I muscle fibers can occur. Increased variation in the diameter of muscle fibers occurs. A lack of evidence of muscle fiber inflammation is reported. There is a distinct lack of necrosis or regeneration of muscle. Less active muscles appear to be affected preferentially. [16]


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